Based on 'The Unity of Heaven and Man': Association Analysis between Air Pollution and Human Health in Beijing and Risk Prediction Using Automated Machine Learning
DOI:
https://doi.org/10.71204/zvj1qm86Keywords:
The Unity of Heaven and Man, Air Pollution, Hematological Parameters, Risk PredictionAbstract
To investigate the correlations between air pollutants and hematological parameters, and to develop a risk prediction model for understanding the health impacts of air pollution, grounded in the traditional Chinese concept of “the unity of heaven and man.”Data collected from 2019 to 2021 in the peripheral areas of Beijing were used. Six air pollutants (PM2.5, PM10, CO, SO2, NO2, O3) and 13 hematological parameters (LYP, MONO, MONP, MP, EOSA, EOSP, BASO, BASOP, MCH, MCHC, SD, PDW, PCT) were analyzed. Analytical methods included Pearson correlation, two-tailed tests, three-dimensional clustering, nonmetric multidimensional scaling, variance partition analysis, redundancy analysis, and multi-group and two-group difference analysis. Automated machine learning (AutoML) was used to predict the trends of air pollutant impacts on health indicators. Long-term exposure to air pollutants was positively correlated with MP, BASO, LYP, and EOSP, and negatively correlated with MCH and PCT. Age emerged as a significant factor influencing health, whereas sex did not modify the effect of air pollution on health indicators. This study provides new evidence on air pollution induced health damage and offers novel insights into the underlying mechanisms of how air pollutants affect human health.
References
Chen, F., Zhang, J., Xie, J., et al. (2025). Causal relationships between air pollutants and upper respiratory tract infections: A two-sample, Mendelian randomization study. Journal of the Chinese Medical Association, 88(6), 481–485.
Deng, Y. L., Liao, J. Q., Zhou, B., et al. (2022). Early life exposure to air pollution and cell-mediated immune responses in preschoolers. Chemosphere, 286(3), Article 131963.
Dziendzikowska, K., Gajewska, M., Wilczak, J., et al. (2018). The effects of 1st and 2nd generation biodiesel exhaust exposure on hematological and biochemical blood indices of Fisher344 male rats - the FuelHealth project. Environmental Toxicology and Pharmacology, 63, 34–47.
Forastiere, F. (2024). Revisiting decades of research on air pollution and acute lower respiratory infections. Annals of the American Thoracic Society, 21(8), 1124–1126.
Foy, B. H., Petherbridge, R., Roth, M., et al. (2025). Haematological setpoints are a stable and patient-specific deep phenotype. Nature, 637(8045), 430–438.
Hu, S., Xu, X., Li, C., et al. (2023). Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: Longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort. BMC Public Health, 23(1), Article 2011.
Huang, H. C., Zou, M. L., Chen, Y. H., et al. (2023). Effects of indoor air quality and home environmental characteristics on allergic diseases among preschool children in the greater Taipei area. Science of the Total Environment, 897, Article 165392.
Karimi, B., & Samadi, S. (2024). Long-term exposure to air pollution on cardio-respiratory, and lung cancer mortality: A systematic review and meta-analysis. Journal of Environmental Health Science and Engineering, 22(1), 75–95.
Krishnan, R. M., Sullivan, J. H., Carlsten, C., et al. (2013). A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Particle and Fibre Toxicology, 10, Article 7.
Lee, J. H., Lee, R., Jang, H., et al. (2025). Association between long-term PM2.5 exposure and risk of infectious diseases- acute otitis media, sinusitis, pharyngitis, and tonsillitis in children: A nationwide longitudinal cohort study. Environmental Research, 272, Article 121137.
Lee, W., Baek, M. C., Kim, K. M., et al. (2020). Biapenem as a novel insight into drug repositioning against particulate matter-induced lung injury. International Journal of Molecular Sciences, 21(4), Article 1462.
Li, C., Jiang, G., & Ren, H. (2022). The common vision toward One Health. Eco-Environment & Health, 1(1), 1–2.
Li, X., Abdullah, L. C., Sobri, S., et al. (2023). Long-term air pollution characteristics and multi-scale meteorological factor variability analysis of mega-mountain cities in the Chengdu-Chongqing economic circle. Water, Air, & Soil Pollution, 234(5), Article 181.
Liu, C., Yang, J., Geng, X., et al. (2024). Intersection of aging and particulate matter 2.5 exposure in real world: Effects on inflammation and endocrine axis activities in rats. International Journal of Endocrinology, 2024, Article 8501696.
Liu, C., Yang, J., Guan, L., et al. (2020). Filtered air intervention reduces inflammation and hypothalamus-pituitary-adrenal axis activation in adult male and female rats after PM2.5 exposure. Environmental Science and Pollution Research, 27(28), 35341–35348.
Liu, F., Zhao, Y., Liu, Y. Q., et al. (2014). Asthma and asthma related symptoms in 23,326 Chinese children in relation to indoor and outdoor environmental factors: The seven Northeastern Cities (snec) study. Science of the Total Environment, 497-498, 10–17.
Liu, J., Wang, P., Shang, L., et al. (2024). Adverse associations of long-term exposure to PM2.5 and its components with platelet traits among subway shift-workers without air purifier use. Toxics, 12(8), Article 529.
Liu, T., Liu, Y., Su, Y., et al. (2024). Air pollution and upper respiratory diseases: An examination among medically insured populations in Wuhan, China. International Journal of Biometeorology, 68(6), 1123–1132.
Lu, C., Wang, F., Liu, Z., et al. (2023). Intrauterine and early postnatal exposure to air pollution associated with childhood allergic rhinitis. Chemosphere, 336, Article 139296.
López-Otín, C., Blasco, M. A., Partridge, L., et al. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243–278.
Meo, S. A., Salih, M. A., Alkhalifah, J. M., et al. (2024). Effect of air pollutants particulate matter PM2.5, PM10, carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3) on fractional exhaled nitric oxide (FeNO). Pakistan Journal of Medical Sciences, 40(8), 1719–1723.
Morales-Ancajima, V. C., Tapia, V., Vu, B. N., et al. (2019). Increased outdoor PM2.5 concentration is associated with moderate/severe anemia in children aged 6-59 months in Lima, Peru. Journal of Environmental and Public Health, 2019, Article 127845.
Nakhjirgan, P., Kashani, H., Naddafi, K., et al. (2023). Exposure to outdoor particulate matter and risk of respiratory diseases: A systematic review and meta-analysis. Environmental Geochemistry and Health, 46(1), Article 20.
Ochoa Scussiatto, H., Stenson, K. M., Al-Khudari, S., et al. (2024). Air pollution is associated with increased incidence-rate of head and neck cancers: A nationally representative ecological study. Oral Oncology, 150, Article 106691.
Odo, D. B., Yang, I. A., Dey, S., et al. (2023). A cross-sectional analysis of ambient fine particulate matter (PM2.5) exposure and haemoglobin levels in children aged under 5 years living in 36 countries. Environmental Research, 227, Article 115734.
Qian, Y., Zhao, Y., Tang, L., et al. (2024). Short-term effects of air pollutants and meteorological factors on outpatients with allergic airway disease in Ningbo, China, 2015-2021. Public Health, 236, 52–59.
Qiu, W., He, H., Wang, B., et al. (2023). Short-term impacts of air pollution on the platelet-lymphocyte ratio and neutrophil-lymphocyte ratio among urban adults in China. Journal of Environmental Sciences, 125, 101–111.
Rudel, R. A., & Perovich, L. J. (2009). Endocrine disrupting chemicals in indoor and outdoor air. Atmospheric Environment, 43(1), 170–181.
Salcan, I., & Salcan, S. (2023). The correlation between air pollution and the allergic rhinitis incidence: Erzincan model. European Review for Medical and Pharmacological Sciences, 27(2 Suppl), 51–56.
Sun, W., Ding, C., Jiang, Z., et al. (2024). The impact of ambient air pollution on allergic rhinitis symptoms: A prospective follow-up study. Toxics, 12(9), Article 663.
Wang, H., & Xue, T. (2026). Aligning climate mitigation, air pollution control, and healthy aging. Health Data Science, 6, Article 0408.
Wang, Q. (2005). Constitution theory of traditional Chinese medicine [In Chinese]. People's Medical Publishing House.
Wise, S. K., Damask, C., Roland, L. T., et al. (2023). International consensus statement on allergy and rhinology: Allergic rhinitis-2023. International Forum of Allergy & Rhinology, 13(4), 293–859.
Wu, L. Y., He, W. T., Zeeshan, M., et al. (2025). Incidence of respiratory diseases associated with per- and polyfluoroalkyl substances (PFAS) in PM2.5: New evidence from a population-based survey of Pearl River Delta (PRD), China. Journal of Hazardous Materials, 494, Article 138485.
Wylie, B. J., Matechi, E., Kishashu, Y., et al. (2017). Placental pathology associated with household air pollution in a cohort of pregnant women from Dar es Salaam, Tanzania. Environmental Health Perspectives, 125(1), 134–140.
Yang, J., Kang, S., Ji, Z., et al. (2020). Investigating air pollutant concentrations and emission control strategies in western China. Chemosphere, 246, Article 125767.
Zhang, Z. Q., Li, J. Y., Guo, Q., et al. (2025). Association between air pollution and allergic upper respiratory diseases: A meta-analysis. European Respiratory Review, 34(176), Article 240266.
Zhong, J., Li, W., Yang, S., et al. (2024). Causal association between air pollution and allergic rhinitis, asthma: A Mendelian randomization study. Frontiers in Public Health, 12, Article 1386341.
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Copyright (c) 2026 Zheng Gong, Wenli Wu, Pengyu Li, Zhanfeng Yan, Xiaoqin Zhou, Ying Zhang, Jingyan Liu (Author)

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