Role of BAZ2A in Cervical Cancer and Its Effect on Tumor Cell Metabolism

Jiarui Xue; Fenglin Dong; Yiwei Liu; Shuqing Wang; Fen Hu; Bin Zhang; Guijie Qi; Zhihao Shen; Rui Guo; Panyan Du; Ying Zhang; Mingjia Zhao; Liyuan Han; Linfeng Zhou; Jinghua Zhang; Yan Liu

doi:10.71204/j7y2f615

Authors

Jiarui Xue North China University of Science and Technology Author
Fenglin Dong North China University of Science and Technology Author
Yiwei Liu North China University of Science and Technology Author
Shuqing Wang North China University of Science and Technology; Hospital of North China University of Science and Technology Author
Fen Hu North China University of Science and Technology Author
Bin Zhang North China University of Science and Technology Author
Guijie Qi North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Zhihao Shen North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Rui Guo North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Panyan Du North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Ying Zhang North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Mingjia Zhao North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Liyuan Han North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Linfeng Zhou North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital Author
Jinghua Zhang North China University of Science and Technology; North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital; Hebei Key Laboratory of Molecular Oncology Author
Yan Liu North China University of Science and Technology; Hebei Key Laboratory of Molecular Oncology Author

DOI:

https://doi.org/10.71204/j7y2f615

Keywords:

BAZ2A, Cervical Cancer, Transcriptome, Metabolome, Enrichment Analysis

Abstract

This study aims to investigate the role of BAZ2A in cervical cancer and its relationship with cancer development and glycolipid metabolism. BAZ2A knockdown experiments were performed in HeLa cells to study its effects on cell proliferation, invasion, cloning and migration; transcriptome and metabolome sequencing were also performed, and differentially expressed genes and metabolites were analyzed by GO and KEGG enrichment, etc. BAZ2A is highly expressed in cervical cancer, and the knockdown of BAZ2A inhibits the related malignant behaviors in HeLa cells. Transcriptome analysis identified a large number of differentially - expressed genes and related pathways, while metabolome analysis identified a variety of different metabolites and related pathways. The joint analysis revealed that key genes and metabolites are involved in the BAZ2A regulatory network, affecting the related signaling pathways. Moreover, BAZ2A plays an important role in cervical cancer development and is closely related to glycolipid metabolism. In conclusion, BAZ2A affects cervical cancer development via cell proliferation, cloning, migration, invasion, and energy metabolism.

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