Research Progress on Comorbid Depression in Epilepsy
DOI:
https://doi.org/10.71204/bxrffv91Keywords:
Epilepsy, Depression, Comorbidity, PathogenesisAbstract
Comorbid depression in epilepsy is a prevalent and severe clinical condition that significantly increases the psychosocial burden of patients. In recent years, with advances in research on its pathological mechanisms, the core biological processes underlying comorbid depression in epilepsy have become increasingly clarified. Its pathogenesis involves multiple pathways, including neurotransmitter imbalance, inflammation, genetic variations, and neuroendocrine abnormalities. This review summarizes the core pathological mechanisms of comorbid depression in epilepsy from four perspectives: neurotransmission, neuroendocrinology, hippocampal structure, and neuroinflammation, aiming to provide theoretical support for clinical diagnosis and treatment.
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Copyright (c) 2026 Xiangfei Meng, Shaoqun Luan, Xin Wu, Sanhui Xu, Ming Zhou (Author)
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