Targeting mTORC1 and AMPK Signaling: Potential Therapeutic Approaches for Idiopathic Pulmonary Fibrosis

Doudou Chen; Yu Liu; Zhihao Xu

doi:10.71204/99f36029

Authors

Doudou Chen Zhejiang University Author
Yu Liu Zhejiang University Author
Zhihao Xu Zhejiang University Author

DOI:

https://doi.org/10.71204/99f36029

Keywords:

Idiopathic Pulmonary Fibrosis, AMPK, mTORC1, Metabolic Reprogramming

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by increasing incidence and mortality. The underlying mechanisms of IPF remain poorly understood, contributing to the limited availability of effective treatments. Current therapies mainly slow disease progression but fail to provide a cure. Consequently, increasing attention has been directed toward modulating signaling pathways such as mammalian target of rapamycin complex 1(mTORC1) and Adenosine monophosphate–activated protein kinase (AMPK), both of which are key regulators of metabolic reprogramming in IPF. This review summarizes recent advances in therapeutic strategies that target cellular metabolism by modulating mTORC1 and AMPK.

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