Advances in World Medical Research
type: channel
description: Advances in World Medical Research (AWMR) is a double-blind peer review process academic journal dedicated to advancing knowledge in the fields of clinical medicine, healthcare, and related disciplines. Core Mission Publish high-quality research, advance knowledge translation, and support clinical practice. Primary Goal Bridge cutting-edge research and clinical needs for global medical progress. Long-term Vision Build a world-class journal with characteristics, as well as amplify Chinese Medicine in global.
publisher: ConnectSix Scholar Publishing INC
language: en
publication name: Advances in World Medical Research
issn: 3068-1812
copyright: All articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are properly credited. Authors retain copyright of their work, and readers are free to copy, share, adapt, and build upon the material for any purpose, including commercial use, as long as appropriate attribution is given.
items: A Study on the Development and Current Status of Curcuma wenyujin and Its Derivatives in the Context of Industrial Modernization: A Case Study of Rui'an City, Wenzhou
items: A Theoretical Study on Consumer Adoption Intentions for Digital Health Products from the Perspective of Information Framing Theory
items: Research Progress on Comorbid Depression in Epilepsy
items: Mechanisms and Research Progress of Traditional Chinese Medicine in the Treatment of Allergic Rhinitis from the Perspective of Modern Medicine
items: A New AI-Enabled Model for Tiered Management of Care Resources for Elderly People with Disabilities in Communities
items: Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory
items: Targeting mTORC1 and AMPK Signaling: Potential Therapeutic Approaches for Idiopathic Pulmonary Fibrosis
items: Advances in Low-Concentration Atropine and Optical Interventions for Myopia Control
items: Astragalus Membranaceus for Type 2 Diabetes Mellitus and Its Complications: From Molecular Mechanisms to Therapeutic Potential
items: Abnormal Expression of WSB1 in Lung Adenocarcinoma: A Potential Prognostic and Immunotherapeutic Sensitivity Biomarker
items: A Study on a Behavioral Intervention Program for Home Non-invasive Positive Pressure Ventilation in Stable COPD Patients Based on the Health Belief Model
items: Research Advances in Lipid Metabolic Reprogramming Mechanisms of Colorectal Cancer Cells
items: Study on the Role and Related Mechanism of ALDH1B1 in the Development of Colorectal Cancer
items: Research Progress on the Relationship Between WSTF and Cancer
items: Scleritis Caused by Eosinophilic Granulomatosis with Polyangiitis: A Case Report
items: Unveiling the Inaugural Issue of Advances in World Medical Research​
items: Analysis of 43 Cases of Difficulties in Removing Artificial Nasolacrimal Duct Stents after Implantation
items: Two-Sample Mendelian Randomization Analysis of the Correlation Between Allergic Rhino-Conjunctivitis and Concomitant Diseases and Peripheral Blood Eosinophil Count
items: Observation on the Efficacy of Self-formulated Huatan Chushi Zhuyu Decoction in the Treatment of Adenoid Hypertrophy in Children and Literature Research on Traditional Chinese Medicine Treatment
items: Role of BAZ2A in Cervical Cancer and Its Effect on Tumor Cell Metabolism

A Study on the Development and Current Status of Curcuma wenyujin and Its Derivatives in the Context of Industrial Modernization: A Case Study of Rui'an City, Wenzhou
type: item
description: As one of the Eight Zhejiang Medicinal Materials, Curcuma wenyujin can be processed into three herbal variants from different medicinal parts. It contains abundant sesquiterpenes and monoterpenes, presenting anti-tumor, anti-inflammatory and antioxidant bioactivities. This study targeted the Curcuma wenyujin industry in Rui’an, Wenzhou, to clarify its current development status and propose targeted improvements for production and sales. Taking local farmers, pharmaceutical enterprises and pharmacy practitioners as research objects, field visits, interviews and questionnaire surveys were applied for empirical analysis. The results indicated that local manufacturers mainly source raw materials from GAP bases to develop health and cosmetic products. However, the industry suffers from low public awareness, high market prices, limited mechanized production and low overall profits. This study identifies major industrial bottlenecks across planting, processing and marketing. It suggests integrating multi-stakeholder demands to stabilize medicinal quality, advance mechanization, strengthen popular science and optimize operational layouts, so as to elevate economic benefits and support the standardized, sustainable development of Curcuma wenyujin and its derivatives.
subject: Articles
  topic: section
subject: Curcuma Wenyujin
  topic: keywords
subject: Plant
  topic: keywords
subject: Derivative Products
  topic: keywords
subject: Practical Application
  topic: keywords
creator: Han Chen
creator: Yueyang Jiang
creator: Yubo Zhang
creator: Chengqiao Liu
creator: Xuchen Lu
creator: Dong Liang
rights: Copyright (c) 2026 Han Chen, Yueyang Jiang, Yubo Zhang, Chengqiao Liu, Xuchen Lu, Dong Liang (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-05-22
publication date: 2026-05-22
starting page: 26
ending page: 39
doi: 10.71204/1kh0p702

A Theoretical Study on Consumer Adoption Intentions for Digital Health Products from the Perspective of Information Framing Theory
type: item
description: This paper adopts Information Framing Theory as its core perspective to conduct a theoretical exploration and conceptual framework construction on existing research regarding consumer adoption intentions for digital health products. The study clarifies the core concepts of Information Framing Theory, constructs an integrated theoretical model combining Information Framing Theory, the Theory of Planned Behavior (TPB), and the Technology Acceptance Model (TAM), and identifies key factors influencing user adoption of digital health products. On this basis, the paper compares the differences in the effects of various information frames and behavioral characteristics of adoption across different scenarios. With a particular focus on the unique characteristics of Traditional Chinese Medicine (TCM) health management scenarios, the paper proposes market optimization strategies based on information framing design. Finally, this paper summarizes the core findings and limitations of the research, offers recommendations for future research directions and corporate practices, and aims to provide theoretical references and practical guidance for the market promotion of TCM-oriented digital health products.
subject: Articles
  topic: section
subject: Information Framing
  topic: keywords
subject: Digital Health Products
  topic: keywords
subject: Consumer Adoption Intentions
  topic: keywords
subject: Traditional Chinese Medicine Health Management
  topic: keywords
subject: Theory of Planned Behavior
  topic: keywords
subject: Technology Acceptance Model
  topic: keywords
creator: Xiaoqi Shao
rights: Copyright (c) 2026 Xiaoqi Shao (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-04-30
publication date: 2026-04-30
starting page: 73
ending page: 82
doi: 10.71204/cqc1yy85

Research Progress on Comorbid Depression in Epilepsy
type: item
description: Comorbid depression in epilepsy is a prevalent and severe clinical condition that significantly increases the psychosocial burden of patients. In recent years, with advances in research on its pathological mechanisms, the core biological processes underlying comorbid depression in epilepsy have become increasingly clarified. Its pathogenesis involves multiple pathways, including neurotransmitter imbalance, inflammation, genetic variations, and neuroendocrine abnormalities. This review summarizes the core pathological mechanisms of comorbid depression in epilepsy from four perspectives: neurotransmission, neuroendocrinology, hippocampal structure, and neuroinflammation, aiming to provide theoretical support for clinical diagnosis and treatment.
subject: Articles
  topic: section
subject: Epilepsy
  topic: keywords
subject: Depression
  topic: keywords
subject: Comorbidity
  topic: keywords
subject: Pathogenesis
  topic: keywords
creator: Xiangfei Meng
creator: Shaoqun Luan
creator: Xin Wu
creator: Sanhui Xu
creator: Ming Zhou
rights: Copyright (c) 2026 Xiangfei Meng, Shaoqun Luan, Xin Wu, Sanhui Xu, Ming Zhou (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-04-25
publication date: 2026-04-25
starting page: 58
ending page: 72
doi: 10.71204/bxrffv91

Mechanisms and Research Progress of Traditional Chinese Medicine in the Treatment of Allergic Rhinitis from the Perspective of Modern Medicine
type: item
description: This article conducts a systematic review of the biological mechanisms and research progress in traditional Chinese medicine (TCM) for treating allergic rhinitis (AR) from a modern medical perspective. Research indicates that TCM exerts systemic therapeutic effects through a multi-target, multi-level network, with core mechanisms focusing on five key areas: first, the regulation of intestinal microecology, reshaping gut microbiota composition and metabolites based on the “gut-nose axis” theory; second, the repair of the mucosal barrier, protecting nasal epithelial cells by modulating programmed cell death pathways such as pyroptosis, autophagy, and ferroptosis; third, the restoration of immune homeostasis, correcting Th1/Th2 and Th17/Treg imbalances and inhibiting IgE-mediated cascade reactions; fourth, the modulation of inflammatory signaling pathways, including TLRs, NF-κB, and MAPK; and fifth, neuro-immune regulation, suppressing neuropeptide release and neurogenic inflammation. Current evidence suggests that TCM offers the advantage of “constitutional regulation and prognosis improvement.” Its integration with conventional therapies can significantly lower AR recurrence rates and mitigate drug-related side effects. To address challenges like lack of standardization and mechanistic opacity in TCM research, this review proposes establishing an evidence-based, standardized diagnostic and therapeutic framework. Utilizing whole-genomics, network pharmacology, and artificial intelligence for precise subtyping and personalized treatment is recommended to advance the modernization and scientific development of TCM in AR management.
subject: Articles
  topic: section
subject: Allergic Rhinitis
  topic: keywords
subject: Integrated Traditional Chinese and Western Medicine
  topic: keywords
subject: Mechanism of Action
  topic: keywords
creator: Ziyang Yu
creator: Zhanfeng Yan
rights: Copyright (c) 2026 Ziyang Yu, Zhanfeng Yan (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-04-23
publication date: 2026-04-23
starting page: 1
ending page: 25
doi: 10.71204/c4x4t363

A New AI-Enabled Model for Tiered Management of Care Resources for Elderly People with Disabilities in Communities
type: item
description: As China’s population ages at an accelerating pace and the number of elderly people with disabilities continues to rise, the traditional family-based care model faces severe challenges, making community-based home care an increasingly important option. However, current community care services suffer from issues such as uneven resource allocation, insufficient service precision and a shortage of professional staff, with a particular lack of intelligent assessment and tiered management mechanisms tailored to elderly people with disabilities .This study, using three communities in Wenzhou, Zhejiang Province as pilot sites, explores the construction of a new integrated community care model—‘assessment-classification-intervention-feedback’—linked by AI-enabled technology. The research comprehensively employs questionnaire surveys, field research, VR virtual simulation training, artificial intelligence predictive models and principal component analysis to establish a four-level coding system based on the Barthel Index, thereby achieving intelligent identification of functional impairment levels among the elderly and differentiated health management.The VR system was utilised for the standardised training of medical student volunteers, thereby enhancing the quality of data collection and service delivery capabilities; the AI predictive models can effectively identify key risk factors for disability; when combined with a digital health management platform, they enable dynamic resource allocation and a closed-loop service system.
subject: Articles
  topic: section
subject: Elderly People with Disabilities
  topic: keywords
subject: AI-Enabled
  topic: keywords
subject: VR Training
  topic: keywords
subject: Tiered Management
  topic: keywords
subject: Smart Care for the Elderly
  topic: keywords
creator: Yueyang Jiang
creator: Han Chen
creator: Wanting Lin
creator: Luyao Pan
creator: Xiangyu Chen
rights: Copyright (c) 2026 Yueyang Jiang, Han Chen, Wanting Lin, Luyao Pan, Xiangyu Chen (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-04-02
publication date: 2026-04-02
starting page: 42
ending page: 57
doi: 10.71204/mb7qv676

Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory
type: item
description: In recent years, the prevalence of allergic rhinitis (AR) in China has increased markedly, significantly impairing patients' quality of life and imposing a substantial socioeconomic burden. Against this background, some scholars have proposed the “Spleen(Stomach)-Lung-Nose Axis” theory based on the Huangdi Neijing, elucidating the close physiological and pathological interconnections among the spleen (stomach), lung, and nose. Guided by this theory, this study correlates the traditional Chinese medicine pathogenesis of AR with modern pathophysiological mechanisms and explores an integrated traditional Chinese and Western medicine therapeutic strategy. This strategy aims to synergize the advantages of both medical systems to provide a more comprehensive and effective treatment regimen for AR, with the goal of alleviating symptoms, improving quality of life, and ultimately reducing the socioeconomic burden.
subject: Articles
  topic: section
subject: Spleen
  topic: keywords
subject: Lung
  topic: keywords
subject: Traditional Chinese Medicine
  topic: keywords
subject: Rhinitis
  topic: keywords
subject: Allergic Rhinitis
  topic: keywords
creator: Yayue Wang
creator: Wei Ji
creator: Linjing Zhang
creator: Lili Liu
creator: Jun Wang
creator: Lan Xue
creator: Zhanfeng Yan
rights: Copyright (c) 2026 Yayue Wang, Wei Ji, Linjing Zhang, Lili Liu, Jun Wang, Lan Xue, Zhanfeng Yan (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-03-15
publication date: 2026-03-15
starting page: 30
ending page: 41
doi: 10.71204/y7b9cz80

Targeting mTORC1 and AMPK Signaling: Potential Therapeutic Approaches for Idiopathic Pulmonary Fibrosis
type: item
description: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by increasing incidence and mortality. The underlying mechanisms of IPF remain poorly understood, contributing to the limited availability of effective treatments. Current therapies mainly slow disease progression but fail to provide a cure. Consequently, increasing attention has been directed toward modulating signaling pathways such as mammalian target of rapamycin complex 1(mTORC1) and Adenosine monophosphate–activated protein kinase (AMPK), both of which are key regulators of metabolic reprogramming in IPF. This review summarizes recent advances in therapeutic strategies that target cellular metabolism by modulating mTORC1 and AMPK.
subject: Articles
  topic: section
subject: Idiopathic Pulmonary Fibrosis
  topic: keywords
subject: AMPK
  topic: keywords
subject: mTORC1
  topic: keywords
subject: Metabolic Reprogramming
  topic: keywords
creator: Doudou Chen
creator: Yu Liu
creator: Zhihao Xu
rights: Copyright (c) 2026 Doudou Chen, Yu Liu, Zhihao Xu (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-02-27
publication date: 2026-02-27
starting page: 1
ending page: 20
doi: 10.71204/99f36029

Advances in Low-Concentration Atropine and Optical Interventions for Myopia Control
type: item
description: Myopia has become a global public health challenge, with its prevalence reaching epidemic proportions in recent decades, particularly in East Asian countries. This comprehensive review synthesizes recent evidence from clinical studies and meta-analyses to examine the efficacy and safety of low-concentration atropine and optical interventions for controlling myopia progression in children and adolescents. We show that low-concentration atropine (specifically 0.01%, 0.025%, and 0.05%) effectively slows myopia progression with a favorable safety profile. Furthermore, we evaluate optical interventions including orthokeratology (Ortho-K), Defocus Incorporated Multiple Segments (DIMS) spectacles, and peripheral progressive addition lenses. Emerging evidence suggests that combination therapy, integrating low-concentration atropine with an optical intervention, may yield superior effects compared to either modality alone. This review also discusses key issues such as treatment personalization, long-term adherence, and future research directions, providing evidence-based insights for clinicians managing childhood myopia.
subject: Articles
  topic: section
subject: Myopia Control
  topic: keywords
subject: Low-concentration atropine
  topic: keywords
subject: Orthokeratology
  topic: keywords
subject: Defocus Incorporated Multiple Segments (DIMS)
  topic: keywords
subject: Combination Therapy
  topic: keywords
creator: Weixing Xu
creator: Yan Zhang
rights: Copyright (c) 2026 Weixing Xu, Yan Zhang (Author) https://creativecommons.org/licenses/by/4.0
date: 2026-02-26
publication date: 2026-02-26
starting page: 21
ending page: 29
doi: 10.71204/h4ject27

Astragalus Membranaceus for Type 2 Diabetes Mellitus and Its Complications: From Molecular Mechanisms to Therapeutic Potential
type: item
description: Astragalus membranaceus is a traditional Chinese medicine widely used in the management of diabetes mellitus. Its major bioactive constituents—astragalus polysaccharides (APS), astragaloside IV (AS-IV), and flavonoids—demonstrate significant anti-diabetic properties. This review summarizes current evidence on the therapeutic potential and molecular mechanisms of A. membranaceus and its major components in treating T2DM and its complications. Literature was retrieved from six databases: PubMed, Science Direct, Academic Journals, Web of Science, Research Gate, and Google Scholar. Search terms included “type 2 diabetes mellitus”, “Astragalus membranaceus”, “polysaccharides”, “saponins”, “flavonoids”, and their combinations. Bioactive compounds from A. membranaceus modulate glucose metabolism and ameliorate insulin resistance (IR). APS restores glucose homeostasis via the PI3K/Akt and AMPK pathways, alleviates endoplasmic reticulum (ER) stress, and regulates gut microbiota. It also confers protection against diabetic cardiomyopathy, nephropathy, cognitive dysfunction, bladder dysfunction, and ulcers through anti-inflammatory, antioxidative, and pro-autophagic activities. AS-IV improves dysregulated glucolipid metabolism by modulating the AMPK/mTOR, ERK1/2, and NF-κB pathways. Flavonoids exert renoprotective effects by mitigating mitochondrial dysfunction and inflammation. A. membranaceus and its bioactive constituents provide a multitargeted strategy to alleviate T2DM and its complications by regulating metabolic, inflammatory, and oxidative stress pathways. However, poor oral bioavailability remains a major limitation for clinical translation. Recent advances in structural modifications and novel delivery systems offer promising avenues to overcome this challenge. As an alternative or adjunctive therapy, A. membranaceus holds considerable potential in diabetes management.
subject: Articles
  topic: section
subject: Astragalus Membranaceus
  topic: keywords
subject: Astragalus Polysaccharides
  topic: keywords
subject: Astragaloside Ⅳ
  topic: keywords
subject: Flavonoids
  topic: keywords
subject: Type 2 diabetes mellitus
  topic: keywords
subject: Diabetic Complications
  topic: keywords
creator: Jiayu Zhang
creator: Wenbo Gao
creator: Shaohua Hu
creator: Ying Liu
rights: Copyright (c) 2025 Jiayu Zhang, Wenbo Gao, Shaohua Hu, Ying Liu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-12-31
publication date: 2025-12-31
starting page: 64
ending page: 97
doi: 10.71204/83zf0y22

Abnormal Expression of WSB1 in Lung Adenocarcinoma: A Potential Prognostic and Immunotherapeutic Sensitivity Biomarker
type: item
description: This study aimed to conduct a pan-cancer analysis of WD40 Repeat-Containing SOCS Box Protein 1 (WSB1) through bioinformatics, detect its expression in lung adenocarcinoma (LUAD) tissues and adjacent normal tissues by immunohistochemistry (IHC), analyze its correlation with clinical indicators, and explore its diagnostic and prognostic value. We performed WSB1 bioinformatics analysis using data from multiple public databases (including TCGA, GTEx, HPA, CPTAC, etc.). IHC was used to detect the expression difference of WSB1 in LUAD tissues and adjacent normal tissues, followed by statistical processing and clinicopathological data analysis. Kaplan-Meier plotter was used to analyze the relationship between WSB1 expression and survival, and GO and KEGG pathway enrichment analyses were conducted to explore its functions. WSB1 was differentially expressed between various cancers and normal tissues. Specifically, WSB1 mRNA levels were downregulated in LUAD, while protein levels were significantly upregulated (P < 0.05). WSB1 expression was negatively correlated with LUAD distant metastasis (P < 0.05) and promoter methylation, and positively correlated with overall survival (OS), tumor immunity, and PDCD1. The genetic variation frequency of WSB1 was >4% (3.18% in LUAD), and there was no correlation with gender, age, etc. IHC validation (80 LUAD samples and 80 adjacent normal tissues) confirmed that WSB1 expression in LUAD tissues was significantly higher than that in adjacent normal tissues. WSB1 is upregulated at the protein level in LUAD and serves as a potential prognostic marker. It correlates with tumor immunity/PDCD1 (as a marker of immunotherapy sensitivity) and promoter methylation (through epigenetic regulation), and its abnormal expression may be caused by high-frequency mutations.
subject: Articles
  topic: section
subject: Lung Adenocarcinoma
  topic: keywords
subject: WSB1
  topic: keywords
subject: Pan-Cancer Analysis
  topic: keywords
subject: Immunohistochemistry
  topic: keywords
creator: Jiarui Xue
creator: Tianying He
creator: Shuqing Wang
creator: Yan Liu
rights: Copyright (c) 2025 Jiarui Xue, Tianying He, Shuqing Wang, Yan Liu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-12-31
publication date: 2025-12-31
starting page: 48
ending page: 63
doi: 10.71204/1bcv8650

A Study on a Behavioral Intervention Program for Home Non-invasive Positive Pressure Ventilation in Stable COPD Patients Based on the Health Belief Model
type: item
description: This study aimed to analyze factors influencing home non-invasive positive pressure ventilation (NPPV) adherence in patients with chronic obstructive pulmonary disease (COPD), and to construct and evaluate the clinical effectiveness of a behavioral intervention program based on the Health Belief Model (HBM). The intervention program was developed through questionnaire surveys and semi-structured interviews with 200 patients, followed by Delphi expert consultations. Subsequently, a 3-month randomized controlled trial (RCT) was conducted to evaluate its efficacy, with the control group receiving conventional health guidance.Post-intervention, the intervention group demonstrated significantly higher total Health Belief Scale scores (4.2 ± 0.3 vs. 2.5 ± 0.4), improved NPPV behavioral adherence (32.4 ± 1.8 vs. 20.1 ± 2.5), and lower CAT scores (10.3 ± 2.1 vs. 20.5 ± 3.2) compared to the control group. Furthermore, blood gas analysis, 6-minute walk test results, and lung function indices were all significantly better in the intervention group (all P < 0.001). Behavioral intervention based on the Health Belief Model can effectively improve NPPV treatment adherence in stable COPD patients, enhance their quality of life, and improve physiological function, demonstrating significant clinical value for promotion.
subject: Articles
  topic: section
subject: Chronic Obstructive Pulmonary Disease
  topic: keywords
subject: Health Belief Model
  topic: keywords
subject: Non-invasive Positive Pressure Ventilation
  topic: keywords
subject: Behavioral Intervention
  topic: keywords
subject: Treatment Adherence
  topic: keywords
creator: Tulei Tian
creator: Lifang Cao
creator: Hongbo Zhang
creator: Jing Xia
creator: Yanyuan Qi
creator: Xiangkun Qu
rights: Copyright (c) 2025 Tulei Tian, Lifang Cao (Author); Hongbo Zhang (Translator); Jing Xia, Yanyuan Qi, Xiangkun Qu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-08-24
publication date: 2025-08-24
starting page: 15
ending page: 25
doi: 10.71204/sc32kv02

Research Advances in Lipid Metabolic Reprogramming Mechanisms of Colorectal Cancer Cells
type: item
description: Colorectal cancer (CRC) is a highly aggressive form of cancer that poses a significant threat to public health worldwide. The progression of this disease is primarily driven by metabolic changes, especially the disruption of lipid metabolism. Cancerous CRC cells proliferate uncontrollably and invade surrounding tissues due to abnormal modifications in fatty acid synthesis, lipid uptake, storage, and β-oxidation. These metabolic shifts are influenced by key oncogenic signaling pathways, such as the PI3K/AKT/mTOR pathway and the MYC transcriptional network, which also enhance interactions with the tumor microenvironment's stromal elements. Recent research suggests that targeting lipid metabolism through pharmacological means could offer substantial clinical benefits. This article provides a comprehensive analysis of the molecular mechanisms involved in the reprogramming of lipid metabolism in CRC development and assesses its potential for innovative therapeutic approaches.
subject: Articles
  topic: section
subject: Colorectal Cancer
  topic: keywords
subject: Lipid Metabolism
  topic: keywords
subject: Metabolic Reprogramming
  topic: keywords
creator: Jin Meng
creator: Yufeng Li
creator: Jingwu Li
rights: Copyright (c) 2025 Jin Meng, Yufeng Li, Jingwu Li (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-08-24
publication date: 2025-08-24
starting page: 26
ending page: 47
doi: 10.71204/gbhp8s96

Study on the Role and Related Mechanism of ALDH1B1 in the Development of Colorectal Cancer
type: item
description: Aldehyde dehydrogenases (ALDHs) comprise a broad superfamily of metabolic enzymes, with 19 gene groups identified in the human genome. These genes participate in diverse biological processes, including the detoxification of exogenous and endogenous aldehydes. In recent years, ALDHs have garnered increasing attention due to their association with stem cell-related characteristics in a wide range of hematopoietic malignancies and solid tumors. ALDH1B1, an isoform and member of the ALDH superfamily, is aberrantly expressed in multiple cancers. For instance, ALDH1B1 is dysregulated in pancreatic cancer (particularly pancreatic ductal adenocarcinoma, PDAC), where it drives tumor progression through multiple mechanisms: maintaining stemness (e.g., activating Notch and Wnt/β-catenin pathways), metabolic reprogramming (acetaldehyde metabolism, reducing toxic aldehyde accumulation while generating NADPH to sustain redox balance), activating oncogenic pathways (e.g., inducing WNT signaling to promote epithelial-mesenchymal transition and enhance invasiveness), and conferring therapy resistance. ALDH1B1 overexpression induces significant changes in cell morphology, proliferation rates, and clonogenic efficiency, thereby contributing to lung adenocarcinoma development. In esophageal carcinogenesis, three genome-wide significant loci in heterozygotes include ALDH1B1, which exhibits a genome-wide significant interaction with rs671, potentially increasing the risk of esophageal cancer (a classic alcohol-associated disease). Domestic studies have shown that miR-761 can target and suppress ALDH1B1 to inhibit osteosarcoma cell proliferation, migration, and invasion. Furthermore, ALDH1B1 promotes colorectal cancer progression by regulating cancer stemness and key oncogenic signaling pathways. This article elucidates the mechanistic roles of ALDH1B1 in various malignancies, with a particular focus on its specific interactions in the development and progression of colorectal cancer. Not…
subject: Articles
  topic: section
subject: ALDH1B1
  topic: keywords
subject: Cancer Stem Cells
  topic: keywords
subject: Wnt/β- Catenin
  topic: keywords
subject: Notch Signaling Pathways
  topic: keywords
subject: Metabolic Reprogramming
  topic: keywords
subject: Malignant Tumors
  topic: keywords
subject: Colorectal Cancer
  topic: keywords
creator: Chi Gao
creator: Jianwei Qiao
creator: Weijie Li
creator: Zhihui Tai
rights: Copyright (c) 2025 Chi Gao, Jianwei Qiao, Weijie Li, Zhihui Tai (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-08-24
publication date: 2025-08-24
starting page: 1
ending page: 14
doi: 10.71204/50ww5z23

Research Progress on the Relationship Between WSTF and Cancer
type: item
description: The Williams syndrome transcription factor (WSTF, alternatively termed BAZ1B) represents a versatile nuclear protein that exerts pleiotropic effects on neurodevelopmental processes, chromatin remodeling, DNA damage repair, as well as transcriptional regulation. Accumulating evidence demonstrates that WSTF is a crucial molecular determinant in the pathogenesis and progression of multiple cancers, positioning it as a viable therapeutic target. This review systematically synthesizes the molecular mechanisms by which WSTF drives oncogenesis across malignancies, focusing on its interplay with regulatory factors and signaling pathways. In breast cancer, WSTF participates in estrogen receptor (ER) signaling and contributes to endocrine therapy resistance by modulating ER-dependent gene expression to promote proliferation and invasion. WSTF also interacts with the vitamin D analog EB1089, suppressing tumor progression through altered promoter binding. In gastric cancer, aberrant WSTF expression disrupts cell adhesion, increasing cancer cell dependency on WSTF. Hyperphosphorylation of WSTF in diffuse gastric cancer further implicates it in tumorigenesis. In cervical, glioblastoma, and lung cancers, WSTF activates the PI3K-Akt signaling cascade, enhancing tumor cell proliferation, migration, and invasion. These findings underscore WSTF’s oncogenic role and therapeutic potential. Further investigation into WSTF’s functions and regulatory mechanisms will deepen our understanding of tumorigenesis and inform novel therapies targeting this chromatin regulator.
subject: Articles
  topic: section
subject: WSTF
  topic: keywords
subject: Malignant Tumors
  topic: keywords
subject: Transcriptional Regulation
  topic: keywords
subject: PI3K/Akt Pathway
  topic: keywords
creator: Yunjie Pei
creator: Yan Liu
creator: Shuqing Wang
creator: Yuanyue Zhang
creator: Jinghua Zhang
rights: Copyright (c) 2025 Yunjie Pei, Yan Liu, Shuqing Wang, Yuanyue Zhang, Jinghua Zhang (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 18
ending page: 33
doi: 10.71204/mny7mr80

Scleritis Caused by Eosinophilic Granulomatosis with Polyangiitis: A Case Report
type: item
description: To report a case of an 81-year-old female with scleritis due to eosinophilic granulomatosis with polyangiitis (EGPA) and emphasize the importance of accurate diagnosis and appropriate management. The patient's initial symptoms, including scleritis and systemic manifestations such as recurrent fever, were observed. Laboratory tests, imaging studies, ANCA testing, and bone marrow biopsy were performed for diagnosis. Treatment with methylprednisolone and cyclophosphamide was administered, and the response was monitored by observing the resolution of scleritis and normalization of blood parameters. The patient was initially misdiagnosed. However, through comprehensive examinations, the EGPA diagnosis was confirmed. The treatment was effective, with the scleritis being resolved and blood parameters returning to normal. EGPA is a rare ANCA-associated vasculitis with complex and non-specific manifestations. ANCA is a significant biomarker, and comprehensive laboratory testing is crucial for accurate diagnosis. Treatment consists of induction and maintenance phases. Ophthalmologists should be aware of the possibility of systemic autoimmune diseases in scleritis patients, especially those with eosinophilia and systemic symptoms, and cooperate with internal medicine specialists for optimal patient management.
subject: Articles
  topic: section
subject: Eosinophilic Granulomatosis with Polyangiitis
  topic: keywords
subject: ANCA
  topic: keywords
subject: Scleritis
  topic: keywords
subject: Autoimmune Disease
  topic: keywords
subject: ANCA-associated Vasculitis
  topic: keywords
creator: Wenbo Hou
creator: Xin Li
creator: Xuguang Sun
rights: Copyright (c) 2025 Wenbo Hou, Xin Li, Xuguang Sun (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 50
ending page: 60
doi: 10.71204/7agtqd88

Unveiling the Inaugural Issue of Advances in World Medical Research​
type: item
description: With immense pride and a deep sense of purpose, we are thrilled to present the inaugural issue of Advances in World Medical Research (AWMR). This milestone marks the beginning of a new chapter in the global pursuit of medical knowledge, innovation, and excellence. As an academic journal committed to a rigorous double-blind peer review process, AWMR is dedicated to advancing the frontiers of clinical medicine, healthcare, and related disciplines, fostering collaboration among researchers, clinicians, and scholars worldwide.​ The first issue of AWMR showcases a diverse range of high-quality research articles that reflect the journal’s broad scope and commitment to interdisciplinary collaboration. We are honored to feature three clinical articles on otorhinolaryngology, delving into the latest diagnostic and treatment approaches for ear, nose, and throat disorders. These studies not only contribute to the understanding of these complex conditions but also provide valuable insights for clinicians seeking to improve patient outcomes.​ In addition to the otorhinolaryngology articles, this issue includes two fundamental research papers on oncology, one of which is a comprehensive review. These studies explore the latest advancements in cancer research, from molecular mechanisms to targeted therapies, offering a glimpse into the future of cancer treatment. By publishing these cutting-edge findings, AWMR aims to inspire further research and innovation in the fight against cancer.​ Finally, we are delighted to present a clinical case report in ophthalmology, highlighting a rare and challenging case that underscores the importance of multidisciplinary collaboration in diagnosing and treating eye diseases. This article serves as a reminder of the critical role that clinical case reports play in sharing valuable experiences and knowledge among healthcare professionals.​ At AWMR, we believe that the exchange of ideas and the dissemination of research findings are essential for th…
subject: Articles
  topic: section
creator: Wei Zhang
rights: Copyright (c) 2025 Wei Zhang (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 1
ending page: 2
doi: 10.71204/pzd0wr39

Analysis of 43 Cases of Difficulties in Removing Artificial Nasolacrimal Duct Stents after Implantation
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description: To explore the causes of difficulties in removing artificial nasolacrimal duct stents after implantation, analyze the bony structural characteristics of the nasolacrimal duct and its impaction causes, and study the structural features of the nasolacrimal duct under paranasal sinus CT, so as to provide references for clinical practice. The clinical data of 43 patients (44 sides) with difficulties in removing artificial nasolacrimal ducts after implantation from October 2018 to June 2022 were retrospectively analyzed, including the patients' age, concurrent diseases, catheterization time, etc. The removal of the nasolacrimal duct was performed under nasal endoscopy, and 40 patients underwent paranasal sinus CT examination. Among the 44 cases of difficult tube removal, 43 cases were successfully removed, and 1 case was not removed. The reasons for the difficulties included the detachment or inversion of the traction wire (30 cases), the impaction of the tube head ring (11 cases), the fracture of the nasolacrimal duct due to long - term catheterization (1 case), and suture fixation during the catheterization operation (1 case). The difficulties in removing artificial nasolacrimal duct stents are related to factors such as the position of the traction wire, the impaction of the tube body, the degeneration of the nasolacrimal duct, and nasal diseases. Feasible solutions were also explored. The bony structural characteristics of the nasolacrimal duct, such as narrowness, curvature, and the influence of surrounding bones, increase the difficulty of tube removal. The paranasal sinus CT of 40 cases can show that the structure of the some nasolacrimal duct is different from that of the normal nasolacrimal duct. The research suggests that clinicians should comprehensively consider various factors to optimize the treatment strategy, providing a reference for clinical surgeries.
subject: Articles
  topic: section
subject: Artificial Nasolacrimal Duct
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subject: Difficulties in Tube Removal
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subject: Nasal Endoscopy
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subject: Bony Structure
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subject: Paranasal Sinus CT
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creator: Jiaxin Chen
creator: Jinxin Chen
creator: Licong Nie
creator: Yonggang Liu
rights: Copyright (c) 2025 Jiaxin Chen, Jinxin Chen, Licong Nie, Yonggang Liu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 71
ending page: 77
doi: 10.71204/qbn44528

Two-Sample Mendelian Randomization Analysis of the Correlation Between Allergic Rhino-Conjunctivitis and Concomitant Diseases and Peripheral Blood Eosinophil Count
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description: To explore the causal relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count from the perspective of single nucleotide polymorphisms through two-sample Mendelian randomization analysis. Five methods, including inverse variance weighting, MR-Egger regression, median weighting, simple model, and weighted model, were used to evaluate the relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count. Sensitivity analysis (pleiotropy, heterogeneity, and leave-one-out test) was used to evaluate the robustness of the results. There was a significant causal association between SNPs of allergic rhinitis , allergic conjunctivitis, asthma, and eczema and SNPs of peripheral blood eosinophil count. The sensitivity analysis of SNP instrumental variables showed no significant heterogeneity or pleiotropy, indicating that the results are robust. Evidence shows that peripheral blood eosinophil count is associated with an increased risk of allergic rhino-conjunctivitis, asthma, and eczema.
subject: Articles
  topic: section
subject: Mendelian Randomization Analysis
  topic: keywords
subject: Allergic Rhino-Conjunctivitis
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subject: Eosinophil Count
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creator: Wei Zhang
creator: Guibao Li
creator: Jingjing Yuan
rights: Copyright (c) 2025 Wei Zhang, Guibao Li, Jingjing Yuan (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 61
ending page: 70
doi: 10.71204/s8ksf005

Observation on the Efficacy of Self-formulated Huatan Chushi Zhuyu Decoction in the Treatment of Adenoid Hypertrophy in Children and Literature Research on Traditional Chinese Medicine Treatment
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description: To observe the clinical efficacy of the self-formulated Huatan Chushi Zhuyu Decoction (HCZ Decoction) combined with basic Western medical treatment in children with moderate to severe adenoid hypertrophy (AH) accompanied by allergic rhinitis (AR), and to explore the theoretical basis by referring to traditional Chinese medicine (TCM) literature. A retrospective analysis was conducted. A total of 64 children with moderate to severe AH admitted to the outpatient department from January 2022 to December 2024 were included and divided into the decoction group (43 cases) and the non-decoction group (41 cases) according to the treatment regimen. The non-decoction group was treated with mometasone furoate nasal spray (100 μg/d) + montelukast (4-5 mg/d) for 2 weeks, combined with cetirizine (5-10 mg/d) for anti-allergy. On this basis, the decoction group was additionally given the HCZ Decoction (including tangerine peel, Poria cocos, Pinellia ternata, licorice, Arisaema cum Bile, peach kernel, Spina Gleditsiae, etc.), one dose per day, taken after breakfast and dinner, with a treatment course of 2 weeks. Baseline data such as age, gender, and BMI of the children in the two groups were collected. The differences in nasal symptom scale, pediatric sleep disorder scale, polysomnography (PSG) parameters, and the degree of AH before and after treatment were compared. The t-test and chi-square test were performed using SPSS 27.0 statistical software, with a significance level of P < 0.05. Chinese databases such as CNKI and Wanfang (from 2014 to 2024) were systematically searched. Using the Citespace 6.3 literature processing tool, the hotspots and clustering information of keywords, institutions, and co-authors related to the TCM treatment of AH in Chinese literature were analyzed. There were no statistical differences in general data and clinical baseline data between the two groups (P > 0.05), indicating comparability. The scores of various items in both the decoction group and …
subject: Articles
  topic: section
subject: Adenoid Hypertrophy
  topic: keywords
subject: Allergic Rhinitis
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subject: Decoction
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creator: Ying Wang
creator: Changwen Che
creator: Mingsheng Zhang
creator: Zhonghai Xin
rights: Copyright (c) 2025 Ying Wang, Changwen Che, Mingsheng Zhang, Zhonghai Xin (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 34
ending page: 49
doi: 10.71204/cp3e9n39

Role of BAZ2A in Cervical Cancer and Its Effect on Tumor Cell Metabolism
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description: This study aims to investigate the role of BAZ2A in cervical cancer and its relationship with cancer development and glycolipid metabolism. BAZ2A knockdown experiments were performed in HeLa cells to study its effects on cell proliferation, invasion, cloning and migration; transcriptome and metabolome sequencing were also performed, and differentially expressed genes and metabolites were analyzed by GO and KEGG enrichment, etc. BAZ2A is highly expressed in cervical cancer, and the knockdown of BAZ2A inhibits the related malignant behaviors in HeLa cells. Transcriptome analysis identified a large number of differentially - expressed genes and related pathways, while metabolome analysis identified a variety of different metabolites and related pathways. The joint analysis revealed that key genes and metabolites are involved in the BAZ2A regulatory network, affecting the related signaling pathways. Moreover, BAZ2A plays an important role in cervical cancer development and is closely related to glycolipid metabolism. In conclusion, BAZ2A affects cervical cancer development via cell proliferation, cloning, migration, invasion, and energy metabolism.
subject: Articles
  topic: section
subject: BAZ2A
  topic: keywords
subject: Cervical Cancer
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subject: Transcriptome
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subject: Metabolome
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subject: Enrichment Analysis
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creator: Jiarui Xue
creator: Fenglin Dong
creator: Yiwei Liu
creator: Shuqing Wang
creator: Fen Hu
creator: Bin Zhang
creator: Guijie Qi
creator: Zhihao Shen
creator: Rui Guo
creator: Panyan Du
creator: Ying Zhang
creator: Mingjia Zhao
creator: Liyuan Han
creator: Linfeng Zhou
creator: Jinghua Zhang
creator: Yan Liu
rights: Copyright (c) 2025 Jiarui Xue, Fenglin Dong, Yiwei Liu, Shuqing Wang, Fen Hu, Bin Zhang, Guijie Qi, Zhihao Shen, Rui Guo, Panyan Du, Ying Zhang, Mingjia Zhao, Liyuan Han, Linfeng Zhou, Jinghua Zhang, Yan Liu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-06-12
publication date: 2025-06-12
starting page: 3
ending page: 17
doi: 10.71204/j7y2f615