Advances in World Medical Research (AWMR) is a double-blind peer review process academic journal dedicated to advancing knowledge in the fields of clinical medicine, healthcare, and related disciplines. Core Mission Publish high-quality research, advance knowledge translation, and support clinical practice. Primary Goal Bridge cutting-edge research and clinical needs for global medical progress. Long-term Vision Build a world-class journal with characteristics, as well as amplify Chinese Medicine in global.
All articles published in this journal are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are properly credited. Authors retain copyright of their work, and readers are free to copy, share, adapt, and build upon the material for any purpose, including commercial use, as long as appropriate attribution is given.
A New AI-Enabled Model for Tiered Management of Care Resources for Elderly People with Disabilities in Communities
As China’s population ages at an accelerating pace and the number of elderly people with disabilities continues to rise, the traditional family-based care model faces severe challenges, making community-based home care an increasingly important option. However, current community care services suffer from issues such as uneven resource allocation, insufficient service precision and a shortage of professional staff, with a particular lack of intelligent assessment and tiered management mechanisms tailored to elderly people with disabilities .This study, using three communities in Wenzhou, Zhejiang Province as pilot sites, explores the construction of a new integrated community care model—‘assessment-classification-intervention-feedback’—linked by AI-enabled technology. The research comprehensively employs questionnaire surveys, field research, VR virtual simulation training, artificial intelligence predictive models and principal component analysis to establish a four-level coding system based on the Barthel Index, thereby achieving intelligent identification of functional impairment levels among the elderly and differentiated health management.The VR system was utilised for the standardised training of medical student volunteers, thereby enhancing the quality of data collection and service delivery capabilities; the AI predictive models can effectively identify key risk factors for disability; when combined with a digital health management platform, they enable dynamic resource allocation and a closed-loop service system.
Copyright (c) 2026 Yueyang Jiang, Han Chen, Wanting Lin, Luyao Pan, Xiangyu Chen (Author) https://creativecommons.org/licenses/by/4.0
Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory
In recent years, the prevalence of allergic rhinitis (AR) in China has increased markedly, significantly impairing patients' quality of life and imposing a substantial socioeconomic burden. Against this background, some scholars have proposed the “Spleen(Stomach)-Lung-Nose Axis” theory based on the Huangdi Neijing, elucidating the close physiological and pathological interconnections among the spleen (stomach), lung, and nose. Guided by this theory, this study correlates the traditional Chinese medicine pathogenesis of AR with modern pathophysiological mechanisms and explores an integrated traditional Chinese and Western medicine therapeutic strategy. This strategy aims to synergize the advantages of both medical systems to provide a more comprehensive and effective treatment regimen for AR, with the goal of alleviating symptoms, improving quality of life, and ultimately reducing the socioeconomic burden.
Copyright (c) 2026 Yayue Wang, Wei Ji, Linjing Zhang, Lili Liu, Jun Wang, Lan Xue, Zhanfeng Yan (Author) https://creativecommons.org/licenses/by/4.0
Mechanisms and Research Progress of Traditional Chinese Medicine in the Treatment of Allergic Rhinitis from the Perspective of Modern Medicine
This article conducts a systematic review of the biological mechanisms and research progress in traditional Chinese medicine (TCM) for treating allergic rhinitis (AR) from a modern medical perspective. Research indicates that TCM exerts systemic therapeutic effects through a multi-target, multi-level network, with core mechanisms focusing on five key areas: first, the regulation of intestinal microecology, reshaping gut microbiota composition and metabolites based on the “gut-nose axis” theory; second, the repair of the mucosal barrier, protecting nasal epithelial cells by modulating programmed cell death pathways such as pyroptosis, autophagy, and ferroptosis; third, the restoration of immune homeostasis, correcting Th1/Th2 and Th17/Treg imbalances and inhibiting IgE-mediated cascade reactions; fourth, the modulation of inflammatory signaling pathways, including TLRs, NF-κB, and MAPK; and fifth, neuro-immune regulation, suppressing neuropeptide release and neurogenic inflammation. Current evidence suggests that TCM offers the advantage of “constitutional regulation and prognosis improvement.” Its integration with conventional therapies can significantly lower AR recurrence rates and mitigate drug-related side effects. To address challenges like lack of standardization and mechanistic opacity in TCM research, this review proposes establishing an evidence-based, standardized diagnostic and therapeutic framework. Utilizing whole-genomics, network pharmacology, and artificial intelligence for precise subtyping and personalized treatment is recommended to advance the modernization and scientific development of TCM in AR management.
Integrated Traditional Chinese and Western Medicine
Copyright (c) 2026 Ziyang Yu, Zhanfeng Yan (Author) https://creativecommons.org/licenses/by/4.0
Targeting mTORC1 and AMPK Signaling: Potential Therapeutic Approaches for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by increasing incidence and mortality. The underlying mechanisms of IPF remain poorly understood, contributing to the limited availability of effective treatments. Current therapies mainly slow disease progression but fail to provide a cure. Consequently, increasing attention has been directed toward modulating signaling pathways such as mammalian target of rapamycin complex 1(mTORC1) and Adenosine monophosphate–activated protein kinase (AMPK), both of which are key regulators of metabolic reprogramming in IPF. This review summarizes recent advances in therapeutic strategies that target cellular metabolism by modulating mTORC1 and AMPK.
Copyright (c) 2026 Doudou Chen, Yu Liu, Zhihao Xu (Author) https://creativecommons.org/licenses/by/4.0
Advances in Low-Concentration Atropine and Optical Interventions for Myopia Control
Myopia has become a global public health challenge, with its prevalence reaching epidemic proportions in recent decades, particularly in East Asian countries. This comprehensive review synthesizes recent evidence from clinical studies and meta-analyses to examine the efficacy and safety of low-concentration atropine and optical interventions for controlling myopia progression in children and adolescents. We show that low-concentration atropine (specifically 0.01%, 0.025%, and 0.05%) effectively slows myopia progression with a favorable safety profile. Furthermore, we evaluate optical interventions including orthokeratology (Ortho-K), Defocus Incorporated Multiple Segments (DIMS) spectacles, and peripheral progressive addition lenses. Emerging evidence suggests that combination therapy, integrating low-concentration atropine with an optical intervention, may yield superior effects compared to either modality alone. This review also discusses key issues such as treatment personalization, long-term adherence, and future research directions, providing evidence-based insights for clinicians managing childhood myopia.
Defocus Incorporated Multiple Segments (DIMS)
Copyright (c) 2026 Weixing Xu, Yan Zhang (Author) https://creativecommons.org/licenses/by/4.0
Astragalus Membranaceus for Type 2 Diabetes Mellitus and Its Complications: From Molecular Mechanisms to Therapeutic Potential
Astragalus membranaceus is a traditional Chinese medicine widely used in the management of diabetes mellitus. Its major bioactive constituents—astragalus polysaccharides (APS), astragaloside IV (AS-IV), and flavonoids—demonstrate significant anti-diabetic properties. This review summarizes current evidence on the therapeutic potential and molecular mechanisms of A. membranaceus and its major components in treating T2DM and its complications. Literature was retrieved from six databases: PubMed, Science Direct, Academic Journals, Web of Science, Research Gate, and Google Scholar. Search terms included “type 2 diabetes mellitus”, “Astragalus membranaceus”, “polysaccharides”, “saponins”, “flavonoids”, and their combinations. Bioactive compounds from A. membranaceus modulate glucose metabolism and ameliorate insulin resistance (IR). APS restores glucose homeostasis via the PI3K/Akt and AMPK pathways, alleviates endoplasmic reticulum (ER) stress, and regulates gut microbiota. It also confers protection against diabetic cardiomyopathy, nephropathy, cognitive dysfunction, bladder dysfunction, and ulcers through anti-inflammatory, antioxidative, and pro-autophagic activities. AS-IV improves dysregulated glucolipid metabolism by modulating the AMPK/mTOR, ERK1/2, and NF-κB pathways. Flavonoids exert renoprotective effects by mitigating mitochondrial dysfunction and inflammation. A. membranaceus and its bioactive constituents provide a multitargeted strategy to alleviate T2DM and its complications by regulating metabolic, inflammatory, and oxidative stress pathways. However, poor oral bioavailability remains a major limitation for clinical translation. Recent advances in structural modifications and novel delivery systems offer promising avenues to overcome this challenge. As an alternative or adjunctive therapy, A. membranaceus holds considerable potential in diabetes management.
Copyright (c) 2025 Jiayu Zhang, Wenbo Gao, Shaohua Hu, Ying Liu (Author) https://creativecommons.org/licenses/by/4.0
Abnormal Expression of WSB1 in Lung Adenocarcinoma: A Potential Prognostic and Immunotherapeutic Sensitivity Biomarker
This study aimed to conduct a pan-cancer analysis of WD40 Repeat-Containing SOCS Box Protein 1 (WSB1) through bioinformatics, detect its expression in lung adenocarcinoma (LUAD) tissues and adjacent normal tissues by immunohistochemistry (IHC), analyze its correlation with clinical indicators, and explore its diagnostic and prognostic value. We performed WSB1 bioinformatics analysis using data from multiple public databases (including TCGA, GTEx, HPA, CPTAC, etc.). IHC was used to detect the expression difference of WSB1 in LUAD tissues and adjacent normal tissues, followed by statistical processing and clinicopathological data analysis. Kaplan-Meier plotter was used to analyze the relationship between WSB1 expression and survival, and GO and KEGG pathway enrichment analyses were conducted to explore its functions. WSB1 was differentially expressed between various cancers and normal tissues. Specifically, WSB1 mRNA levels were downregulated in LUAD, while protein levels were significantly upregulated (P < 0.05). WSB1 expression was negatively correlated with LUAD distant metastasis (P < 0.05) and promoter methylation, and positively correlated with overall survival (OS), tumor immunity, and PDCD1. The genetic variation frequency of WSB1 was >4% (3.18% in LUAD), and there was no correlation with gender, age, etc. IHC validation (80 LUAD samples and 80 adjacent normal tissues) confirmed that WSB1 expression in LUAD tissues was significantly higher than that in adjacent normal tissues. WSB1 is upregulated at the protein level in LUAD and serves as a potential prognostic marker. It correlates with tumor immunity/PDCD1 (as a marker of immunotherapy sensitivity) and promoter methylation (through epigenetic regulation), and its abnormal expression may be caused by high-frequency mutations.
Copyright (c) 2025 Jiarui Xue, Tianying He, Shuqing Wang, Yan Liu (Author) https://creativecommons.org/licenses/by/4.0
A Study on a Behavioral Intervention Program for Home Non-invasive Positive Pressure Ventilation in Stable COPD Patients Based on the Health Belief Model
This study aimed to analyze factors influencing home non-invasive positive pressure ventilation (NPPV) adherence in patients with chronic obstructive pulmonary disease (COPD), and to construct and evaluate the clinical effectiveness of a behavioral intervention program based on the Health Belief Model (HBM). The intervention program was developed through questionnaire surveys and semi-structured interviews with 200 patients, followed by Delphi expert consultations. Subsequently, a 3-month randomized controlled trial (RCT) was conducted to evaluate its efficacy, with the control group receiving conventional health guidance.Post-intervention, the intervention group demonstrated significantly higher total Health Belief Scale scores (4.2 ± 0.3 vs. 2.5 ± 0.4), improved NPPV behavioral adherence (32.4 ± 1.8 vs. 20.1 ± 2.5), and lower CAT scores (10.3 ± 2.1 vs. 20.5 ± 3.2) compared to the control group. Furthermore, blood gas analysis, 6-minute walk test results, and lung function indices were all significantly better in the intervention group (all P < 0.001). Behavioral intervention based on the Health Belief Model can effectively improve NPPV treatment adherence in stable COPD patients, enhance their quality of life, and improve physiological function, demonstrating significant clinical value for promotion.
Non-invasive Positive Pressure Ventilation
Copyright (c) 2025 Tulei Tian, Lifang Cao (Author); Hongbo Zhang (Translator); Jing Xia, Yanyuan Qi, Xiangkun Qu (Author) https://creativecommons.org/licenses/by/4.0
Research Advances in Lipid Metabolic Reprogramming Mechanisms of Colorectal Cancer Cells
Colorectal cancer (CRC) is a highly aggressive form of cancer that poses a significant threat to public health worldwide. The progression of this disease is primarily driven by metabolic changes, especially the disruption of lipid metabolism. Cancerous CRC cells proliferate uncontrollably and invade surrounding tissues due to abnormal modifications in fatty acid synthesis, lipid uptake, storage, and β-oxidation. These metabolic shifts are influenced by key oncogenic signaling pathways, such as the PI3K/AKT/mTOR pathway and the MYC transcriptional network, which also enhance interactions with the tumor microenvironment's stromal elements. Recent research suggests that targeting lipid metabolism through pharmacological means could offer substantial clinical benefits. This article provides a comprehensive analysis of the molecular mechanisms involved in the reprogramming of lipid metabolism in CRC development and assesses its potential for innovative therapeutic approaches.
Copyright (c) 2025 Jin Meng, Yufeng Li, Jingwu Li (Author) https://creativecommons.org/licenses/by/4.0
Study on the Role and Related Mechanism of ALDH1B1 in the Development of Colorectal Cancer
Aldehyde dehydrogenases (ALDHs) comprise a broad superfamily of metabolic enzymes, with 19 gene groups identified in the human genome. These genes participate in diverse biological processes, including the detoxification of exogenous and endogenous aldehydes. In recent years, ALDHs have garnered increasing attention due to their association with stem cell-related characteristics in a wide range of hematopoietic malignancies and solid tumors. ALDH1B1, an isoform and member of the ALDH superfamily, is aberrantly expressed in multiple cancers. For instance, ALDH1B1 is dysregulated in pancreatic cancer (particularly pancreatic ductal adenocarcinoma, PDAC), where it drives tumor progression through multiple mechanisms: maintaining stemness (e.g., activating Notch and Wnt/β-catenin pathways), metabolic reprogramming (acetaldehyde metabolism, reducing toxic aldehyde accumulation while generating NADPH to sustain redox balance), activating oncogenic pathways (e.g., inducing WNT signaling to promote epithelial-mesenchymal transition and enhance invasiveness), and conferring therapy resistance. ALDH1B1 overexpression induces significant changes in cell morphology, proliferation rates, and clonogenic efficiency, thereby contributing to lung adenocarcinoma development. In esophageal carcinogenesis, three genome-wide significant loci in heterozygotes include ALDH1B1, which exhibits a genome-wide significant interaction with rs671, potentially increasing the risk of esophageal cancer (a classic alcohol-associated disease). Domestic studies have shown that miR-761 can target and suppress ALDH1B1 to inhibit osteosarcoma cell proliferation, migration, and invasion. Furthermore, ALDH1B1 promotes colorectal cancer progression by regulating cancer stemness and key oncogenic signaling pathways. This article elucidates the mechanistic roles of ALDH1B1 in various malignancies, with a particular focus on its specific interactions in the development and progression of colorectal cancer. Notably, ALDH1B1 promotes colorectal carcinogenesis by mediating unique metabolic reprogramming processes. On one hand, ALDH1B1 maintains intracellular redox balance through acetaldehyde oxidation, creating a favorable metabolic microenvironment for cancer stem cells. On the other hand, its involvement in retinoic acid metabolism dysregulation aberrantly activates key oncogenic pathways such as Wnt/β-catenin signaling. Furthermore, ALDH1B1 enhances the glycolytic switch (the Warburg effect) by modulating mitochondrial energy metabolism, thereby supplying the bioenergetic and biosynthetic precursors required for rapid tumor cell proliferation. These metabolic regulatory mechanisms synergize with ALDH1B1’s role in sustaining cancer stem cell properties, collectively forming a multidimensional network through which ALDH1B1 drives colorectal cancer progression. A deeper understanding of the logical relationship between ALDH1B1-mediated metabolic regulation and carcinogenesis will provide a more comprehensive insight into its role in various cancers, particularly colorectal cancer, and offer a theoretical foundation for developing novel ALDH1B1-targeted therapeutic strategies. However, more detailed molecular mechanisms, clinical relevance, and potential therapeutic value require further experimental and clinical validation.
Copyright (c) 2025 Chi Gao, Jianwei Qiao, Weijie Li, Zhihui Tai (Author) https://creativecommons.org/licenses/by/4.0
Research Progress on the Relationship Between WSTF and Cancere
The Williams syndrome transcription factor (WSTF, alternatively termed BAZ1B) represents a versatile nuclear protein that exerts pleiotropic effects on neurodevelopmental processes, chromatin remodeling, DNA damage repair, as well as transcriptional regulation. Accumulating evidence demonstrates that WSTF is a crucial molecular determinant in the pathogenesis and progression of multiple cancers, positioning it as a viable therapeutic target. This review systematically synthesizes the molecular mechanisms by which WSTF drives oncogenesis across malignancies, focusing on its interplay with regulatory factors and signaling pathways. In breast cancer, WSTF participates in estrogen receptor (ER) signaling and contributes to endocrine therapy resistance by modulating ER-dependent gene expression to promote proliferation and invasion. WSTF also interacts with the vitamin D analog EB1089, suppressing tumor progression through altered promoter binding. In gastric cancer, aberrant WSTF expression disrupts cell adhesion, increasing cancer cell dependency on WSTF. Hyperphosphorylation of WSTF in diffuse gastric cancer further implicates it in tumorigenesis. In cervical, glioblastoma, and lung cancers, WSTF activates the PI3K-Akt signaling cascade, enhancing tumor cell proliferation, migration, and invasion. These findings underscore WSTF’s oncogenic role and therapeutic potential. Further investigation into WSTF’s functions and regulatory mechanisms will deepen our understanding of tumorigenesis and inform novel therapies targeting this chromatin regulator.
Copyright (c) 2025 Yunjie Pei, Yan Liu, Shuqing Wang, Yuanyue Zhang, Jinghua Zhang (Author) https://creativecommons.org/licenses/by/4.0
Scleritis Caused by Eosinophilic Granulomatosis with Polyangiitis: A Case Reporte
To report a case of an 81-year-old female with scleritis due to eosinophilic granulomatosis with polyangiitis (EGPA) and emphasize the importance of accurate diagnosis and appropriate management. The patient's initial symptoms, including scleritis and systemic manifestations such as recurrent fever, were observed. Laboratory tests, imaging studies, ANCA testing, and bone marrow biopsy were performed for diagnosis. Treatment with methylprednisolone and cyclophosphamide was administered, and the response was monitored by observing the resolution of scleritis and normalization of blood parameters. The patient was initially misdiagnosed. However, through comprehensive examinations, the EGPA diagnosis was confirmed. The treatment was effective, with the scleritis being resolved and blood parameters returning to normal. EGPA is a rare ANCA-associated vasculitis with complex and non-specific manifestations. ANCA is a significant biomarker, and comprehensive laboratory testing is crucial for accurate diagnosis. Treatment consists of induction and maintenance phases. Ophthalmologists should be aware of the possibility of systemic autoimmune diseases in scleritis patients, especially those with eosinophilia and systemic symptoms, and cooperate with internal medicine specialists for optimal patient management.
Eosinophilic Granulomatosis with Polyangiitis
Copyright (c) 2025 Wenbo Hou, Xin Li, Xuguang Sun (Author) https://creativecommons.org/licenses/by/4.0
Unveiling the Inaugural Issue of Advances in World Medical Research​
With immense pride and a deep sense of purpose, we are thrilled to present the inaugural issue of Advances in World Medical Research (AWMR). This milestone marks the beginning of a new chapter in the global pursuit of medical knowledge, innovation, and excellence. As an academic journal committed to a rigorous double-blind peer review process, AWMR is dedicated to advancing the frontiers of clinical medicine, healthcare, and related disciplines, fostering collaboration among researchers, clinicians, and scholars worldwide.​ The first issue of AWMR showcases a diverse range of high-quality research articles that reflect the journal’s broad scope and commitment to interdisciplinary collaboration. We are honored to feature three clinical articles on otorhinolaryngology, delving into the latest diagnostic and treatment approaches for ear, nose, and throat disorders. These studies not only contribute to the understanding of these complex conditions but also provide valuable insights for clinicians seeking to improve patient outcomes.​ In addition to the otorhinolaryngology articles, this issue includes two fundamental research papers on oncology, one of which is a comprehensive review. These studies explore the latest advancements in cancer research, from molecular mechanisms to targeted therapies, offering a glimpse into the future of cancer treatment. By publishing these cutting-edge findings, AWMR aims to inspire further research and innovation in the fight against cancer.​ Finally, we are delighted to present a clinical case report in ophthalmology, highlighting a rare and challenging case that underscores the importance of multidisciplinary collaboration in diagnosing and treating eye diseases. This article serves as a reminder of the critical role that clinical case reports play in sharing valuable experiences and knowledge among healthcare professionals.​ At AWMR, we believe that the exchange of ideas and the dissemination of research findings are essential for the advancement of medical science. Our journal provides a platform for researchers and clinicians to share their work, engage in scholarly discourse, and contribute to the global medical community. We invite submissions from researchers, clinicians, and scholars worldwide, covering a wide range of topics within the fields of clinical medicine, healthcare, and related disciplines.​ As we embark on this exciting journey, we are committed to maintaining the highest standards of academic integrity, quality, and excellence. We look forward to working with you to shape the future of medical research and contribute to the improvement of healthcare worldwide.​ Welcome to Advances in World Medical Research. We hope you enjoy reading this inaugural issue and look forward to your continued support and participation in our journal.
Copyright (c) 2025 Wei Zhang (Author) https://creativecommons.org/licenses/by/4.0
Analysis of 43 Cases of Difficulties in Removing Artificial Nasolacrimal Duct Stents after Implantation
To explore the causes of difficulties in removing artificial nasolacrimal duct stents after implantation, analyze the bony structural characteristics of the nasolacrimal duct and its impaction causes, and study the structural features of the nasolacrimal duct under paranasal sinus CT, so as to provide references for clinical practice. The clinical data of 43 patients (44 sides) with difficulties in removing artificial nasolacrimal ducts after implantation from October 2018 to June 2022 were retrospectively analyzed, including the patients' age, concurrent diseases, catheterization time, etc. The removal of the nasolacrimal duct was performed under nasal endoscopy, and 40 patients underwent paranasal sinus CT examination. Among the 44 cases of difficult tube removal, 43 cases were successfully removed, and 1 case was not removed. The reasons for the difficulties included the detachment or inversion of the traction wire (30 cases), the impaction of the tube head ring (11 cases), the fracture of the nasolacrimal duct due to long - term catheterization (1 case), and suture fixation during the catheterization operation (1 case). The difficulties in removing artificial nasolacrimal duct stents are related to factors such as the position of the traction wire, the impaction of the tube body, the degeneration of the nasolacrimal duct, and nasal diseases. Feasible solutions were also explored. The bony structural characteristics of the nasolacrimal duct, such as narrowness, curvature, and the influence of surrounding bones, increase the difficulty of tube removal. The paranasal sinus CT of 40 cases can show that the structure of the some nasolacrimal duct is different from that of the normal nasolacrimal duct. The research suggests that clinicians should comprehensively consider various factors to optimize the treatment strategy, providing a reference for clinical surgeries.
Copyright (c) 2025 Jiaxin Chen, Jinxin Chen, Licong Nie, Yonggang Liu (Author) https://creativecommons.org/licenses/by/4.0
Two-Sample Mendelian Randomization Analysis of the Correlation Between Allergic Rhino-Conjunctivitis and Concomitant Diseases and Peripheral Blood Eosinophil Count
To explore the causal relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count from the perspective of single nucleotide polymorphisms through two-sample Mendelian randomization analysis. Five methods, including inverse variance weighting, MR-Egger regression, median weighting, simple model, and weighted model, were used to evaluate the relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count. Sensitivity analysis (pleiotropy, heterogeneity, and leave-one-out test) was used to evaluate the robustness of the results. There was a significant causal association between SNPs of allergic rhinitis , allergic conjunctivitis, asthma, and eczema and SNPs of peripheral blood eosinophil count. The sensitivity analysis of SNP instrumental variables showed no significant heterogeneity or pleiotropy, indicating that the results are robust. Evidence shows that peripheral blood eosinophil count is associated with an increased risk of allergic rhino-conjunctivitis, asthma, and eczema.
Copyright (c) 2025 Wei Zhang, Guibao Li, Jingjing Yuan (Author) https://creativecommons.org/licenses/by/4.0
Observation on the Efficacy of Self-formulated Huatan Chushi Zhuyu Decoction in the Treatment of Adenoid Hypertrophy in Children and Literature Research on Traditional Chinese Medicine Treatment
To observe the clinical efficacy of the self-formulated Huatan Chushi Zhuyu Decoction (HCZ Decoction) combined with basic Western medical treatment in children with moderate to severe adenoid hypertrophy (AH) accompanied by allergic rhinitis (AR), and to explore the theoretical basis by referring to traditional Chinese medicine (TCM) literature. A retrospective analysis was conducted. A total of 64 children with moderate to severe AH admitted to the outpatient department from January 2022 to December 2024 were included and divided into the decoction group (43 cases) and the non-decoction group (41 cases) according to the treatment regimen. The non-decoction group was treated with mometasone furoate nasal spray (100 μg/d) + montelukast (4-5 mg/d) for 2 weeks, combined with cetirizine (5-10 mg/d) for anti-allergy. On this basis, the decoction group was additionally given the HCZ Decoction (including tangerine peel, Poria cocos, Pinellia ternata, licorice, Arisaema cum Bile, peach kernel, Spina Gleditsiae, etc.), one dose per day, taken after breakfast and dinner, with a treatment course of 2 weeks. Baseline data such as age, gender, and BMI of the children in the two groups were collected. The differences in nasal symptom scale, pediatric sleep disorder scale, polysomnography (PSG) parameters, and the degree of AH before and after treatment were compared. The t-test and chi-square test were performed using SPSS 27.0 statistical software, with a significance level of P < 0.05. Chinese databases such as CNKI and Wanfang (from 2014 to 2024) were systematically searched. Using the Citespace 6.3 literature processing tool, the hotspots and clustering information of keywords, institutions, and co-authors related to the TCM treatment of AH in Chinese literature were analyzed. There were no statistical differences in general data and clinical baseline data between the two groups (P > 0.05), indicating comparability. The scores of various items in both the decoction group and the non-decoction group decreased after treatment, confirming the effectiveness of the treatment. The total score of OSA-18 was at the moderate to severe level, and there were differences in the total score and the changes of various scores between the decoction group and the non-decoction group, with the scores of the decoction group being lower. There was a difference in the change score of the total nasal symptom score (TNSS) between the two groups, mainly manifested in nasal obstruction and sneezing. There were no differences in the changes of OAHI and LSaO2 scores between the two groups. The literature study showed that the core therapeutic methods of TCM treatment for AH are "resolving phlegm, removing dampness, and promoting blood circulation to remove blood stasis", which highly coincides with the compatibility of the self-formulated decoction. The HCZ Decoction combined with basic Western medical treatment can significantly improve the nasal symptoms and sleep quality of children with moderate to severe AH accompanied by AR. Its curative effect may be achieved by regulating the local inflammatory response rather than reducing the volume of the adenoids. TCM literature supports that ‘the intermingling of phlegm, blood stasis, and dampness’ is the core pathogenesis of AH. This decoction provides a safe and effective non-surgical treatment option for clinical practice.
Copyright (c) 2025 Ying Wang, Changwen Che, Mingsheng Zhang, Zhonghai Xin (Author) https://creativecommons.org/licenses/by/4.0
Role of BAZ2A in Cervical Cancer and Its Effect on Tumor Cell Metabolism
This study aims to investigate the role of BAZ2A in cervical cancer and its relationship with cancer development and glycolipid metabolism. BAZ2A knockdown experiments were performed in HeLa cells to study its effects on cell proliferation, invasion, cloning and migration; transcriptome and metabolome sequencing were also performed, and differentially expressed genes and metabolites were analyzed by GO and KEGG enrichment, etc. BAZ2A is highly expressed in cervical cancer, and the knockdown of BAZ2A inhibits the related malignant behaviors in HeLa cells. Transcriptome analysis identified a large number of differentially - expressed genes and related pathways, while metabolome analysis identified a variety of different metabolites and related pathways. The joint analysis revealed that key genes and metabolites are involved in the BAZ2A regulatory network, affecting the related signaling pathways. Moreover, BAZ2A plays an important role in cervical cancer development and is closely related to glycolipid metabolism. In conclusion, BAZ2A affects cervical cancer development via cell proliferation, cloning, migration, invasion, and energy metabolism.
Copyright (c) 2025 Jiarui Xue, Fenglin Dong, Yiwei Liu, Shuqing Wang, Fen Hu, Bin Zhang, Guijie Qi, Zhihao Shen, Rui Guo, Panyan Du, Ying Zhang, Mingjia Zhao, Liyuan Han, Linfeng Zhou, Jinghua Zhang, Yan Liu (Author) https://creativecommons.org/licenses/by/4.0